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SP-A is responsible for surfactanthomeostasis (regulating synthesis and secretion of surfac-tant by type II alveolar cells). When cases were strati?ed according to p53 status and Pin1 expression levels,overall survival was found to be signi?cantly decreased in patients with tumorsexpressing high levels of Pin1 and p53 missense mutations, compared to cases with lowPin1 expression and p53 missense mutations, or cases bearing wild-type p53 [ 11 ].In addition, p53 mutation correlates with shorter OS only in cases with high Pin1expression levels.

Unlike on the spe-cialty neonatal ventilators, PSV on these devicesdoes not have a backup rate and thus requires areliable respiratory effort, not often present in pre-term infants.

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