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Outcome studies further showthat patients who undergo resection have a better qual-ity of life and are less likely to become depressed thanpatients who undergo only biopsy (Pietila et al., 1999).For patients with unresectable lesions (most often due tothe anatomic location being associated with an unaccept-able risk of neurologic deficit) or with associated signifi -cant medical comorbidities, a stereotactic biopsy for tis-sue diagnosis is sufficient. The cAMP mediatedproton pump activation also involves Ca2+

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